Pancreas Islet Patient Selection Criteria

Indications

1. All recipients must have Type I insulin-dependent Diabetes Mellitus with absent C-peptide
2. Previous kidney transplant (or kidney-pancreas transplant with failed pancreas with satisfactory kidney graft function)
3. GFR >50 based on calculated GFR, or based on a 24 hour urine study, or base on iothalamate clearance as appropriate (This is to only apply to patients who have not previously received a kidney transplant and are potential kidney recipients)
4. Kidney transplant candidates with Type I insulin-dependent Diabetes Mellitus

Contraindications

1. History of malignancy (except adequately treated localized basal cell carcinoma of skin without evidence of recurrence, or other cancers considered cured by therapy)
2. Patients with current episodes of acute renal allograft rejection
3. Patients with panel reactive antibody (PRA) level > 50%
4. Chemical dependency, including illegal narcotic usage (i.e. marijuana), not consistent with screening criteria in Substance Dependence Addendum
5. Active infection
6. Non-compliance